Can quinine cause infertility?

The reports from some of these studies using animal models have shown that quinine possesses anti-spermatogenic activities: disrupts spermatogenesis, reduces sperm motility, morphology and sperm count and is deleterious to testicular histoarchitecture8–10.

What is quinine sulphate used for?

Quinine sulfate at a dose of 200–300 mg at night has been used for many years to treat nocturnal leg cramps. Usually idiopathic, these muscle cramps are common, particularly in older patients. Quinine may help by decreasing the excitability of the motor end-plate and increasing the muscle refractory period.

Is quinine safe in first trimester?

Pregnancies exposed to quinine or chloroquine and carried to term did not have increased rates of congenital abnormality, stillbirth or low birthweight. These results suggest that therapeutic doses of quinine and chloroquine are safe to use in the first trimester of pregnancy.

Why is quinine bad in pregnancy?

Pregnant women have risk for a rare triad of complications: massive hemolysis, hemoglobinemia, and hemoglobinuria. In high doses, this drug causes fetal harm including deafness, development disturbances, and extremity and cranium malformations.

Can I drink quinine while pregnant?

Is it safe to take quinine in pregnancy? You should not avoid taking quinine because you are pregnant. The risk of harm to you and your baby from malaria is likely to be far greater than any possible risk from taking quinine. There is no convincing scientific evidence that quinine is harmful to an unborn baby.

What is tonic water with quinine in it good for?

Tonic water is a soft drink containing quinine, which gives it a bitter taste. Quinine is a common treatment for malaria. Some people believe that it can also help with leg cramps and restless legs syndrome. Quinine comes from the bark of the cinchona tree.

Is it safe to take quinine sulfate during pregnancy?

You should not take quinine sulfate when you are pregnant or breast-feeding, unless the benefits outweigh the risks. This medicine should not be used to treat cramps during pregnancy. Large doses of quinine can cause foetal abnormalities or induce abortion.

Which is the correct name for quinine sulfate?

Quinine is a basic amine and is usually provided as a salt. Various existing preparations include the hydrochloride, dihydrochloride, sulfate, bisulfate and gluconate. In the United States, quinine sulfate is commercially available in 324-mg tablets under the brand name Qualaquin.

How does quinine work in the placenta during pregnancy?

Quinine crosses the placenta and gives measurable blood concentrations in the fetus. In 8 women who delivered live infants 1 to 6 days after starting quinine therapy, placental cord plasma quinine levels were between 1.0 and 4.6 mg/L and the ratio of cord plasma to maternal plasma quinine levels averaged 0.32.

When to take quinine sulfate for night cramps?

Quinine sulfate belongs to a group of medicines called anti- protozoal agents and they are used: • to treat malaria • to treat and prevent night cramps in adults and the elderly when sleep is regularly disrupted 2 What you need to know before you take

Can quinine cause infertility? The reports from some of these studies using animal models have shown that quinine possesses anti-spermatogenic activities: disrupts spermatogenesis, reduces sperm motility, morphology and sperm count and is deleterious to testicular histoarchitecture8–10. What is quinine sulphate used for? Quinine sulfate at a dose of 200–300 mg at night has been used…