What does S6 kinase do?

S6 kinases (S6Ks) are mechanistic target of rapamycin substrates that participate in cell growth control. S6Ks phosphorylate ribosomal protein S6 (rpS6) and additional proteins involved in the translational machinery, although the functional roles of these modifications remain elusive.

What is P p70S6K?

Abstract. The pp70/85-kDa S6 kinases, collectively referred to as pp70S6k, are thought to participate in transit through the G1 phase of the cell cycle. pp70S6k regulates the phosphorylation of the 40S ribosomal protein S6 and the transcription factor CREM tau.

What is S6K in biology?

S6K is a serine/threonine kinase that is a member of the ribosomal S6 kinase (RSK) family. S6K exists in two main isoforms, S6K1 and S6K2, which can also be alternatively spliced to produce different splice forms.

What activates mTORC1?

Most specifically, carbohydrate consumption activates mTORC1 through the insulin growth factor pathway. In addition, amino acid consumption will stimulate mTORC1 through the branched chain amino acid/Rag pathway.

What activates S6K?

In the classical insulin signaling pathway, S6K is activated by mTOR at the downstream of PI3K/Akt. The activation involves in S6K phosphorylation at T389 by mTOR, which enhances protein synthesis through phosphorylation of ribosomal protein S6 by S6K.

What is a mTOR?

A protein that helps control several cell functions, including cell division and survival, and binds to rapamycin and other drugs. mTOR may be more active in some types of cancer cells than it is in normal cells. Blocking mTOR may cause the cancer cells to die. It is a type of serine/threonine protein kinase.

How is mTOR activated?

Activation of mTOR complex 1 (mTORC1) is triggered by oxidative stress, amino-acid levels and endosomal traffic to the lysosome by small GTPases such as Rab4A. In turn, mTORC1 promotes inflammation by skewing T-cell development.

Is mTOR and mTORC1 the same?

mTOR Complex 1 (mTORC1) is composed of mTOR itself, regulatory-associated protein of mTOR (commonly known as raptor), mammalian lethal with SEC13 protein 8 (MLST8), PRAS40 and DEPTOR. …

Is mTOR good or bad?

Think of high mTOR activity being an analog of the phrase “Live fast, die young”, because too much activity is good for growth but bad for lifespan. However, too little mTOR activity is not beneficial either and can disrupt healing and insulin sensitivity and can cause cataracts in mouse models [1].

What kind of kinase is p70 S6 kinase 1?

Ribosomal protein S6 kinase beta-1 ( S6K1 ), also known as p70S6 kinase ( p70S6K, p70-S6K ), is an enzyme (specifically, a protein kinase) that in humans is encoded by the RPS6KB1 gene. It is a serine/threonine kinase that acts downstream of PIP3 and phosphoinositide-dependent kinase-1 in the PI3 kinase pathway.

Is the S6 kinase involved in signal transduction?

Some of the signalling events involving rsk. In molecular biology, ribosomal s6 kinase ( rsk) is a family of protein kinases involved in signal transduction. There are two subfamilies of rsk, p90 rsk, also known as MAPK-activated protein kinase-1 (MAPKAP-K1), and p70 rsk, also known as S6-H1 Kinase or simply S6 Kinase.

What is the gene for ribosomal protein S6K1?

Ribosomal protein S6 kinase beta-1 (S6K1), also known as p70S6 kinase (p70S6K, p70-S6K), is an enzyme (specifically, a protein kinase) that in humans is encoded by the RPS6KB1 gene.

How are P70 and S6K1 involved in muscle growth?

Another pathway for which P70 has proposed involvement is in muscle lengthening and growing. P70 is phosphorylated by passive stretch in the soleus muscle. This may be one of many protein kinases involved in muscle building. In its inactive state, S6K1 is bound to eIF3 and detaches following phosphorylation by mTOR / Raptor.

What does S6 kinase do? S6 kinases (S6Ks) are mechanistic target of rapamycin substrates that participate in cell growth control. S6Ks phosphorylate ribosomal protein S6 (rpS6) and additional proteins involved in the translational machinery, although the functional roles of these modifications remain elusive. What is P p70S6K? Abstract. The pp70/85-kDa S6 kinases, collectively referred to…