Is gentamicin ototoxicity reversible?

Ototoxicity is irreversible and may result in cochlear damage, vestibular damage or both. Incidence of cochlear and vestibular toxicity is low in children and neonates. There is no significant difference in the incidence of ototoxicity between once daily dosing and multiple doses per day.

How does gentamicin cause ototoxicity?

Initial studies suggested that uptake of gentamicin by the inner ear rapidly leads to saturation but the drug is only slowly released. Prolonged exposure of hair cells to aminoglycoside is the probable cause of damage.

Is ototoxicity permanent?

Ototoxicity can be temporary or permanent. The effect of certain drugs is often temporary, while other drugs typically produce permanent changes to the ear.

Can gentamicin cause neurotoxicity?

Common side effects of gentamicin include: Neurotoxicity (spinning sensation [vertigo], loss of control of bodily movements) Gait instability. Ototoxicity (auditory, vestibular)

Are there any cases of gentamicin ototoxicity?

Aminoglycoside ototoxicity: vestibular function is also vulnerable. BMJ 2007; 335: 952. 1. Dobie RA, Black FO, Pezsnecker SC, Stallings VL. Hearing loss in patients with vestibulotoxic reactions to gentamicin therapy. Arch Otolaryngol Head Neck Surg 2006; 132: 253-257.

How many patients have been diagnosed with gentamicin vestibulotoxicity?

Over the 23-year period, 552 patients were diagnosed with severe, symmetrical, selective (ie, normal hearing for age), bilateral vestibular loss. Of these, 263 patients had gentamicin vestibulotoxicity (GVT).

What are the possible side effects of gentamicin?

Gentamicin is an important bactericidal antibiotic with two serious potential adverse effects: nephrotoxicity and ototoxicity. Clinicians are well aware that rising serum creatinine levels in patients treated with gentamicin could indicate nephrotoxicity.

How are streptomycin and gentamicin different from each other?

Among them, streptomycin and gentamicin are primarily vestibulotoxic, whereas amikacin, neomycin, dihydrosterptomycin, and kanamicin are primarily cochleotoxic. Cochlear damage can produce permanent hearing loss, and damage to the vestibular apparatus results in dizziness, ataxia, and/or nystagmus.

Is gentamicin ototoxicity reversible? Ototoxicity is irreversible and may result in cochlear damage, vestibular damage or both. Incidence of cochlear and vestibular toxicity is low in children and neonates. There is no significant difference in the incidence of ototoxicity between once daily dosing and multiple doses per day. How does gentamicin cause ototoxicity? Initial studies…