What is ecallantide used for?

Ecallantide injection is used to treat sudden attacks of hereditary angioedema (HAE). Ecallantide works by blocking a chemical in the body that causes swelling, inflammation, and pain for patients with HAE. This medicine is not a cure for HAE.

What is the brand name for icatibant?

FIRAZYR® (icatibant injection) is the registered name (also known as the “brand name”) for the treatment that is manufactured by Takeda and was approved by the FDA in 2011. Icatibant is the active ingredient in FIRAZYR.

Which medications are used to treat acute attacks of HAE?

Medications currently approved for the treatment of acute HAE attacks include various forms of C1-INH (both plasma-derived and recombinant), icatibant (a reversible, competitive antagonist of the bradykinin type 2 receptor), and ecallantide (a reversible kallikrein inhibitor).

How fast does Ruconest work?

Individual results may vary.

In the primary clinical study, patients treated with RUCONEST started to see symptom relief in 90 minutes vs 152 minutes with placebo.
In an extension of the study, patients started to see symptom relief in 75 minutes.

What company makes ecallantide?

Ecallantide (Kalbitor®, known as DX-88 previously) is a recombinant kallikrein inhibitor developed by Dyax Corporation. This is the only product approved recently by the FDA for all localizations of edematous HAE attacks occurring in patients over 16 years of age.

When do you use icatibant?

Icatibant injection is used to treat sudden attacks of hereditary angioedema (HAE). Icatibant works by blocking a chemical in the body that causes swelling, inflammation, and pain for patients with HAE.

Is icatibant FDA approved?

Cipla has received final approval from the U.S. Food and Drug Administration (FDA) for a generic version of Firazyr (icatibant injection), an approved treatment for acute attacks in adults with hereditary angioedema (HAE).

Who treats angioedema?

Your allergist will examine your welts or areas of swelling and take a careful medical history to identify possible causes. In some cases you may need an allergy skin test. If your doctor suspects you have hereditary angioedema, he or she may order a blood test to check for specific blood proteins.

Is hereditary angioedema an autoimmune disease?

Hereditary angioedema may be associated with autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, autoimmune thyroiditis and glomerulonephritis.

How is Ruconest administered?

Recommended Dosing The recommended dose of RUCONEST is 50 U per kg with a maximum of 4200 U to be administered as a slow intravenous injection over approximately 5 minutes.

What is the treatment for hereditary angioedema?

Treatment of Hereditary Angioedema: Replacement therapy or immune modulating medicines pertaining to hereditary angioedema. Intravenous medication to treat acute attacks of hereditary angioedema. To prevent angioedema due to C1 esterase inhibitor deficiency.

Is ecallantide FDA approved?

December 4, 2009 — The US Food and Drug Administration (FDA) has approved ecallantide subcutaneous injection (Kalbitor, Dyax Corp) for the treatment of sudden and potentially fatal fluid build-up associated with hereditary angioedema (HAE) in patients aged 16 years and older.

What kind of drug is ecallantide used for?

Ecallantide (trade name Kalbitor) is a drug used for the treatment of hereditary angioedema (HAE) and in the prevention of blood loss in cardiothoracic surgery. It is an inhibitor of the protein kallikrein and a 60- amino acid polypeptide which was developed from a Kunitz domain through phage display to mimic antibodies…

How is ecallantide an inhibitor of kallikrein?

It is an inhibitor of the protein kallikrein and a 60- amino acid polypeptide which was developed from a Kunitz domain through phage display to mimic antibodies inhibiting kallikrein. On November 27, 2009, ecallantide was approved by the FDA for the treatment of acute attacks of hereditary angioedema for persons over 16 years of age.

How old do you have to be to take ecallantide?

On November 27, 2009, ecallantide was approved by the FDA for the treatment of acute attacks of hereditary angioedema for persons over 16 years of age. For angioedema due to ACE inhibitors it does not appear to have a benefit.

How is ecallantide used in cardiothoracic surgery?

Ecallantide (trade name Kalbitor) is a drug used for the treatment of hereditary angioedema (HAE) and in the prevention of blood loss in cardiothoracic surgery. It is an inhibitor of the protein kallikrein and a 60-amino acid polypeptide which was developed from a Kunitz domain through phage display to mimic antibodies inhibiting kallikrein.

What is ecallantide used for? Ecallantide injection is used to treat sudden attacks of hereditary angioedema (HAE). Ecallantide works by blocking a chemical in the body that causes swelling, inflammation, and pain for patients with HAE. This medicine is not a cure for HAE. What is the brand name for icatibant? FIRAZYR® (icatibant injection) is…