Is idiopathic short stature a disease?

ISS is a clinical description rather than a disease. ISS is generally considered a normal variant of growth (since pathologic causes are excluded by definition).

What causes idiopathic short stature?

Idiopathic short stature (ISS) comprises a wide range of conditions associated with short stature that elude the conventional diagnostic work-up and are often caused by still largely unknown genetic variants.

What is 3rd percentile?

On your child’s Road to Health chart, there are 4 clear curves or “roads”. The top one is called the 97th percentile; Then there is the slightly darker curve, called the 50th percentile; Underneath this you’ll find the 3rd percentile; En the lowest curve which is called the 60% of the 50th percentile.

What is the treatment for idiopathic short stature?

Children with Idiopathic Short Stature do not attain a normal adult height. The improvement of adult height with treatment with recombinant human growth hormone (rhGH), at doses of 0.16 to 0.28 mg/kg/week is modest, usually less that 4 cm, and they remain short as adults.

How is short stature defined?

Short stature is a general term used to describe a condition in which a child or a teen’s height is well below the average height of his or her peers. Short stature typically means that a person’s height is below that of the shortest 3 percent to 5 percent of children of the same age and sex.

What is idiopathic short stature syndrome?

Idiopathic short stature (ISS) is defined as a condition characterized by a height more than 2 standard deviations below the corresponding average height for a given age, sex and population, without findings of disease.

What does it mean if my child is in the 3rd percentile?

A child who has a height plotted below the third percentile line is considered to have short stature compared with the general population.

How tall do you have to be to have idiopathic short stature?

Idiopathic short stature. ISS can be defined as a condition in which the height of an individual is more than 2 SD below the corresponding mean height for a given age, sex, and population group without evidence of systemic, endocrine, nutritional, or chromosomal abnormalities.

What are the different types of short stature?

Most children with short stature have normal variants such as familial short stature, constitutional delay of growth and puberty, or idiopathic short stature.

Is the height of a child a pathologic condition?

Although most children with short or tall stature do not have a pathologic condition, extremes of height, especially beyond three standard deviations, require further workup. Calculating the midparental height ( Table 1) is an important part of the evaluation because most short or tall children have short or tall parents.

What are the causes of short stature in children?

Common normal variants of short stature are familial short stature, constitutional delay of growth and puberty, and idiopathic short stature. Pathologic causes of short stature include chronic diseases; growth hormone deficiency; and genetic disorders, such as Turner syndrome.

Is idiopathic short stature a disease? ISS is a clinical description rather than a disease. ISS is generally considered a normal variant of growth (since pathologic causes are excluded by definition). What causes idiopathic short stature? Idiopathic short stature (ISS) comprises a wide range of conditions associated with short stature that elude the conventional diagnostic…