Does heterogeneous mean malignant?
Does heterogeneous mean malignant?
Introduction. Cancer is a heterogeneous disease. Practically from the moment pathologists first looked at human cancers under the microscope, they saw that differing histologic appearances could define distinct subtypes of cancers from the same primary site of origin.
What causes tumor heterogeneity?
This heterogeneity does not depend on genetic or epigenetic mechanisms but is instead caused by apparently noise-driven differences in levels of protein expression [22]. Plasticity of tumor cell phenotype is not limited to apoptotic response.
What does it mean to have a heterogeneous uterus?
The heterogeneous appearance of the myometrium includes uterine enlargement and asymmetry of the anterior or posterior myometrial wall.
Can you tell if a mass is cancerous with an MRI?
MRI is very good at finding and pinpointing some cancers. An MRI with contrast dye is the best way to see brain and spinal cord tumors. Using MRI, doctors can sometimes tell if a tumor is or isn’t cancer.
Why is heterogeneity important in the treatment of cancer?
The heterogeneity of cancer cells introduces significant challenges in designing effective treatment strategies. However, research into understanding and characterizing heterogeneity can allow for a better understanding of the causes and progression of disease.
Why are some tumours more heterogeneous than others?
Similarly, intra-tumour heterogeneity relates to the genetic heterogeneity between cancer cells within a single tumour, and might explain why some tumour cells remain present in the patient after cancer treatment has finished. Both can lead to different and unpredictable responses to therapy, including use of targeted therapy approaches.
How is intrapatient tumor heterogeneity a clinical challenge?
Intrapatient tumor heterogeneity presents multiple clinical challenges, from the initial diagnosis to the treatment of metastatic disease. At diagnosis, a cancer treatment plan is made, based largely on the pathology results from a single tissue sample of a primary site.
What is tumor heterogeneity at Memorial Sloan Kettering?
At Memorial Sloan Kettering and at other research centers around the world, the push is on to characterize the molecular variations between tumors — known as inter-tumor heterogeneity — and offer individualized treatments to more patients. That alone is a massive task.
Does heterogeneous mean malignant? Introduction. Cancer is a heterogeneous disease. Practically from the moment pathologists first looked at human cancers under the microscope, they saw that differing histologic appearances could define distinct subtypes of cancers from the same primary site of origin. What causes tumor heterogeneity? This heterogeneity does not depend on genetic or epigenetic…