How do you know if you have a balanced translocation?
How do you know if you have a balanced translocation?
Sometimes a section from one chromosome of a particular pair changes places with a section from a chromosome of another pair. When the two breaks do not pass through a gene and there is no gain or loss of material when the chromosomes are looked at under a microscope, it is called a balanced translocation.
What happens in a balanced translocation?
A balanced or chromosomal translocation is a condition in which part of a chromosome has broken off and reattached in another location. In other words, it means that sections of two chromosomes have switched places.
What negative effects does translocation have?
Translocations are more often associated with negative consequences such as aneuploidy, infertility, or cancer.
What diseases are caused by translocation?
Examples
| Translocation | Associated diseases | Fused genes/proteins |
|---|---|---|
| First | ||
| t(9;22)(q34;q11) Philadelphia chromosome | Chronic myelogenous leukemia (CML), acute lymphoblastic leukemia (ALL) | Abl1 gene on chromosome 9 |
| t(15;17)(q22;q21) | Acute promyelocytic leukemia | PML protein on chromosome 15 |
What causes unbalanced translocation?
An unbalanced translocation occurs when a fetus inherits a chromosome with extra or missing genetic material from a parent with a balanced translocation.
Can you have a healthy baby with balanced translocation?
Natural conception and live birth is possible in cases of balanced translocation, but those with the condition may have more difficulty conceiving and are at a greater risk of recurrent miscarriage than those without it.
What causes translocation?
Translocation Down syndrome is a type of Down syndrome that is caused when one chromosome breaks off and attaches to another chromosome. In this case, there are three 21 chromosomes, but one of the 21 chromosomes is attached to another chromosome.
What are the symptoms of a balanced translocation patient?
1 a balanced translocation patient reports severe depressed mood (8%) 7 balanced translocation patients report moderate depressed mood (58%) 3 balanced translocation patients report mild depressed mood (25%)
How does balanced translocation lead to a miscarriage?
What Balanced Translocation Means. However, when that person’s cells divide to create an egg or sperm cells for reproduction, the egg or sperm cells can end up with extra genetic material or missing genetic material, which could lead to miscarriage depending on which chromosome and genes are affected.
Can a person have translocation without being aware of the condition?
In the case of the former, many people can have translocations without being aware of the condition.
When do chromosomes change places in a balanced translocation?
Sometimes a section from one chromosome of a particular pair changes places with a section from a chromosome of another pair. When the two breaks do not pass through a gene and there is no gain or loss of material when the chromosomes are looked at under a microscope, it is called a balanced translocation.
How do you know if you have a balanced translocation? Sometimes a section from one chromosome of a particular pair changes places with a section from a chromosome of another pair. When the two breaks do not pass through a gene and there is no gain or loss of material when the chromosomes are looked…