How long can you live with double hit lymphoma?

A 2014 multicenter retrospective study of 311 patients with double-hit lymphoma showed median progression-free survival to be 11 months and median overall survival to be 22 months.

What is double hit and triple hit lymphoma?

Double-hit and triple-hit lymphomas are high-grade B-cell lymphomas that have major genetic changes (mutations) affecting particular genes. The genes that are affected are called MYC, BCL2 and BCL6. These genes usually help control the growth of B cells. Double-hit lymphomas have mutations in two of these genes.

What is the survival rate of triple hit lymphoma?

Patients with triple hit lymphoma had a very poor prognosis, with an overall survival of 18 months, similar to the overall survival of patients with MYC/BCL6 double hit lymphoma (17 months) and those with MYC/BCL2 double hit lymphoma (20 months) (Fig.

How bad is double hit lymphoma?

Patients with double-hit lymphomas have a poor prognosis when treated with standard chemoimmunotherapy and have increased risk of central nervous system involvement and progression. Double-hit lymphomas may arise as a consequence of the transformation of the underlying indolent lymphoma.

Does double-hit lymphoma come back?

Patients with double-hit lymphoma (DHL) rarely achieve long-term survival following disease relapse. Some patients with DHL undergo consolidative autologous stem-cell transplantation (autoSCT) to reduce the risk of relapse, although the benefit of this treatment strategy is unclear.

Is GREY zone lymphoma curable?

Grey zone lymphoma is an aggressive disease that can be difficult to treat, however it is potentially curable with standard treatment that includes combination chemotherapy and immunotherapy (chemoimmunotherapy), sometimes with radiotherapy and stem cell transplant.

How is triple-hit lymphoma treated?

In summary, triple-hit lymphomas are clinically aggressive tumors associated with a poor prognosis. Patients often respond poorly to chemotherapy, but a subset may completely respond to chemotherapy followed by stem cell transplant.

Where does non-Hodgkin’s lymphoma occur?

Non-Hodgkin’s lymphoma generally involves the presence of cancerous lymphocytes in your lymph nodes. But the disease can also spread to other parts of your lymphatic system. These include the lymphatic vessels, tonsils, adenoids, spleen, thymus and bone marrow.

Is double-hit lymphoma rare?

A rare, aggressive (fast-growing) type of B-cell non-Hodgkin lymphoma caused by changes in the DNA that affect a gene called the MYC gene and either the BCL2 gene or the BCL6 gene. Double-hit lymphoma may be hard to treat and has a poor prognosis.

Can you survive double expressor lymphoma?

Patients carrying the double expression of MYC and BCL2 (double expressor, DE) with or without concomitant translocations of MYC and BCL2, and/or BCL6 genes have a dismal prognosis. In patients affected by DE DLBCL without translocations, the 5-year overall survival (OS) is ~40% with R-CHOP.

How do I treat “double hit” lymphoma?

Relapsed Double-Hit Lymphoma. The standard curative approach to the treatment of relapsed aggressive lymphoma in fit patients is to administer non-cross-resistant salvage chemotherapy followed by consolidation with high-dose therapy and AHCT, but outcomes in patients with MYC-rearranged disease are poor.

What is the survival rate for double hit lymphoma?

All the double-hit lymphoma patients possessed both nodal and extranodal involvement. The overall complete response rate was 89.3%, overall survival 87.1% and progression-free survival 75.8% over 2 years (median observation period: 644 days).

What is the prognosis for double hit lymphoma?

The prognosis of Double Hit Lymphoma depends on many factors including the subtype and stage of lymphoma, progression of the condition, response to treatment, and overall health of the individual. However, typically the prognosis of DHL is poor.

What is treatment for triple hit lymphoma?

If Triple Hit Lymphoma is not fully responsive to treatment, or if the chance of recurrence is high, then bone marrow transplantation or stem cell transplantation can be considered In order to prevent infections because the immune system is weakened by the lymphoma or by its treatment,…

How long can you live with double hit lymphoma? A 2014 multicenter retrospective study of 311 patients with double-hit lymphoma showed median progression-free survival to be 11 months and median overall survival to be 22 months. What is double hit and triple hit lymphoma? Double-hit and triple-hit lymphomas are high-grade B-cell lymphomas that have major…