What are the symptoms of Pendred syndrome?

Pendred syndrome is a condition usually characterized by sensorineural hearing loss in both ears (bilateral) and euthyroid goiter (enlargement of the thyroid gland with normal thyroid gland function). The amount of hearing loss varies among affected people. In many cases, significant hearing loss is present at birth.

Is Pendred syndrome hereditary?

Because it is a recessive trait, a child needs to inherit two mutated SLC26A4 genes—one from each parent—to have Pendred syndrome. Since the child’s parents are only carriers of a mutation in the SLC26A4 gene, there are no health implications for them.

Is Pendred syndrome congenital?

Pendred syndrome is a genetic disorder leading to congenital bilateral (both sides) sensorineural hearing loss and goitre with euthyroid or mild hypothyroidism (decreased thyroid gland function).

What is the function of Pendrin?

Pendrin is responsible for mediating the electroneutral exchange of chloride (Cl−) for bicarbonate (HCO3−) across a plasma membrane in the chloride cells of freshwater fish. By phylogenetic analysis, pendrin has been found to be a close relative of prestin present on the hair cells or organ of corti in the inner ear.

What is Refetoff syndrome?

Refetoff Syndrome: Thyroid hormone resistance is a rare syndrome in which thyroid hormone levels are elevated but the thyroid stimulating hormone (TSH) level is not suppressed (or not completely suppressed as would be expected).

What is a Mondini malformation?

Mondini dysplasia is a type of inner ear malformation that is present at birth ( congenital ). Individuals with Mondini dysplasia have one and a half coils of the cochlea instead of the normal two coils.

Is iodide the same as iodine?

Iodine in food and iodized salt is present in several chemical forms including sodium and potassium salts, inorganic iodine (I2), iodate, and iodide, the reduced form of iodine [4]. Iodine rarely occurs as the element, but rather as a salt; for this reason, it is referred to as iodide and not iodine.

Is ADHD linked to thyroid problems?

Unsurprisingly, thyroid disease can promote the occurrence of many chronic conditions including ADD/ADHD. Research shows that those with a generalized resistance to thyroid hormone are far more likely to have ADHD when compared to other family members with healthy thyroid function.

What is secondary thyroid disease?

Secondary hypothyroidism is a rare disorder that describes an underactive pituitary gland causing an underactive thyroid. The pituitary gland produces thyroid-stimulating hormone, also called thyrotropin. As you can tell from the name, this pituitary hormone is needed for normal thyroid function.

What causes sudden hearing loss?

The causes of sudden hearing loss include: trauma, such as head injuries or damage to the eardrum caused by a foreign object, an extremely loud noise or ear surgery. barotrauma. ototoxic medications, such as gentamicin, furosemide (Lasix), or large doses of aspirin. infections including viruses. neurologic disorders.

What are the symptoms of congenital hearing loss?

Some of the comorbid or associated medical symptoms for Congenital hearing loss in children may include these symptoms: Head symptoms. Face symptoms. Nerve symptoms. Eye symptoms. Sensations. Deafness.

Is deafness hereditary?

Hereditary deafness is a condition that is passed to children from one or both parents through genetic makeup. The end result is hearing loss, which may or may not be present from birth. For some children, it simply means that they are predisposed to suffering from hearing loss later in life.

What are the symptoms of Pendred syndrome? Pendred syndrome is a condition usually characterized by sensorineural hearing loss in both ears (bilateral) and euthyroid goiter (enlargement of the thyroid gland with normal thyroid gland function). The amount of hearing loss varies among affected people. In many cases, significant hearing loss is present at birth. Is…