What causes Hand Schuller Christian disease?

Chronic otitis media due to involvement of the mastoid and the temporal bone is common. Diabetes insipidus affects some patients, mainly children who have systemic disease. Up to 40% of children with it have short stature. Hand-Schuller-Christian disease is a form of Langerhans cell histiocytosis.

What is letterer SIWE disease?

Letterer-Siwe disease (LSD) is one of the Langerhans cell histiocytoses (LCH). Physiologically, Langerhans cells detect non-self-antigens and present them to the cells of the immune system (T cells), thus allowing an appropriate immune response from the body.

What is Langerhans histiocytosis?

Langerhans cell histiocytosis is a rare disorder that can damage tissue or cause lesions to form in one or more places in the body. Langerhans cell histiocytosis (LCH) is a rare disease that begins in LCH cells. LCH cells are a type of dendritic cell that normally helps the body fight infection.

What does a Histiocyte do?

A histiocyte is a normal immune cell that is found in many parts of the body especially in the bone marrow, the blood stream, the skin, the liver, the lungs, the lymph glands and the spleen. In histiocytosis, the histiocytes move into tissues where they are not normally found and cause damage to those tissues.

What layer of the skin are Langerhans cells found?

Langerhans cells (LCs) reside in the epidermis as a dense network of immune system sentinels. These cells determine the appropriate adaptive immune response (inflammation or tolerance) by interpreting the microenvironmental context in which they encounter foreign substances.

What does a letterer do?

A letterer is a member of a team of comic book creators responsible for drawing the comic book’s text. The letterer’s use of typefaces, calligraphy, letter size, and layout all contribute to the impact of the comic.

What is the survival rate of Langerhans Cell Histiocytosis?

What are the survival rates for Langerhans cell histiocytosis? About 99% of children with low-risk LCH survive. About 80% of children with high-risk LCH survive.

Is LCH a leukemia?

This suggests that LCH is a type of neoplastic disease (a disease grouping that includes benign, pre-cancerous and cancerous growths). Langerhans cell histiocytosis may occur at any age, but is most common in young children under 10. LCH is classified as either unifocal (one site) or multifocal (multiple sites).

Is LCH an autoimmune disease?

Langerhans cell histiocytosis historically was thought of as a cancer-like condition, but more recently researchers have begun to consider it an autoimmune phenomenon in which immune cells begin to overproduce and attack the body instead of fighting infection.

Are Langerhans part of the immune system?

Langerhans cells (LC) are members of the dendritic cells family, residing in the basal and suprabasal layers of the epidermis and in the epithelia of the respiratory, digestive and urogenital tracts. They specialize in antigen presentation and belong to the skin immune system (SIS).

What do Langerhans cells look like?

Langerhans cell is represented by a yellow oval; blue arrows correspond to is_a relations, and orange arrows correspond to develops_from relations.

What causes Hand Schuller Christian disease? Chronic otitis media due to involvement of the mastoid and the temporal bone is common. Diabetes insipidus affects some patients, mainly children who have systemic disease. Up to 40% of children with it have short stature. Hand-Schuller-Christian disease is a form of Langerhans cell histiocytosis. What is letterer SIWE…