What disability is Wolfram syndrome?

Wolfram syndrome , which is also known by the acronym DIDMOAD, is an inherited condition characterized by diabetes insipidus (DI), childhood-onset diabetes mellitus (DM), a gradual loss of vision caused by optic atrophy (OA), and deafness (D).

What are the symptoms of Wolfram syndrome?

The primary symptoms of Wolfram syndrome (diabetes mellitus, optic atrophy, diabetes insipidus and hearing loss) can emerge at different ages and change at different rates. If some of these symptoms never appear at all, the patient’s condition would be called a WFS1-related disorder.

Is Wolfram syndrome curable?

Although there are currently no effective treatments that can delay, halt, or reverse the progression of Wolfram syndrome, the use of careful clinical monitoring and supportive care can relieve the debilitating symptoms.

How common is Wolfram syndrome?

The estimated prevalence of Wolfram syndrome type 1 is 1 in 500,000 people worldwide. Approximately 200 cases have been described in the scientific literature.

What are the 4 most common features of Wolfram syndrome?

Wolfram Syndrome is a rare genetic disorder which is also known as DIDMOAD syndrome after its four most common features (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy and Deafness).

What is Mauriac syndrome?

Mauriac syndrome (MS) is a glycogenic hepatopathy, initially described in 1930, characterized by growth failure, delayed puberty, cushingoid appearance, hepatomegaly with abnormal liver enzymes, and hypercholesterolemia.

What is Bardet Biedl syndrome?

Bardet-Biedl syndrome (BBS) is a genetic condition that impacts multiple body systems. It is classically defined by six features. Patients with BBS can experience problems with obesity, specifically with fat deposition along the abdomen. They often also suffer from intellectual impairments.

What is Alström syndrome?

Alström syndrome is characterized by a progressive loss of vision and hearing, a form of heart disease that enlarges and weakens the heart muscle (dilated cardiomyopathy ), obesity, type 2 diabetes (the most common form of diabetes), and short stature.

What are the signs of diabetes in a teenager?

Symptoms

Increased thirst and frequent urination. Excess sugar building up in your child’s bloodstream pulls fluid from tissues.
Fatigue. Lack of sugar in your child’s cells might make him or her exhausted.
Blurry vision.
Darkened areas of skin.
Weight loss.

What is a brittle diabetic?

Brittle diabetes is diabetes that’s especially difficult to manage and often disrupts everyday life. People with brittle diabetes have severe swings in blood glucose (blood sugar). The swings can cause frequent episodes of hypoglycemia (low blood sugar) or hyperglycemia (high blood sugar).

What is the life expectancy of someone with Bardet-Biedl syndrome?

Kidney disease is also frequent and is a major cause of early death for individuals with BBS, though complications of obesity, heart disease, and diabetes have also been reported as causes of death. However, a majority of individuals may have a normal or near-normal life expectancy, though with various impairments.

What kind of genetic disorder is Wolfram syndrome?

Wolfram syndrome, also called DIDMOAD (diabetes insipidus, diabetes mellitus, optic atrophy, and deafness), is a rare autosomal-recessive genetic disorder that causes childhood-onset diabetes mellitus, optic atrophy, and deafness as well as various other possible disorders. It was first described in four siblings in 1938 by Dr. Don J. Wolfram, M.D.

What kind of hearing loss does Wolfram syndrome cause?

In addition, many people with Wolfram syndrome also develop diabetes insipidus and sensorineural hearing loss. An older name for the syndrome is DIDMOAD, which refers to diabetes insipidus, diabetes mellitus, optic atrophy, and deafness.

When do you know if you have Wolfram syndrome?

Diabetes mellitus is typically the first symptom of Wolfram syndrome, usually diagnosed around age 6. Nearly everyone with Wolfram syndrome who develops diabetes mellitus requires insulin replacement therapy. Optic atrophy is often the next symptom to appear, usually around age 11.

Is the optic atrophy in Wolfram syndrome the same?

The optic atrophy in LHOA and the optic atrophy in Wolfram syndrome may look the same and have the same symptoms. LHOA can start in one eye or both, but both eyes are usually affected within six months. In most people, vision loss is permanent.

What disability is Wolfram syndrome? Wolfram syndrome , which is also known by the acronym DIDMOAD, is an inherited condition characterized by diabetes insipidus (DI), childhood-onset diabetes mellitus (DM), a gradual loss of vision caused by optic atrophy (OA), and deafness (D). What are the symptoms of Wolfram syndrome? The primary symptoms of Wolfram syndrome…