What does a high beta 2 globulin mean?

People with cancers of the bone marrow and blood often have high levels of B2M in their blood or urine. These cancers include multiple myeloma, lymphoma, and leukemia. High levels of B2M in cerebrospinal fluid can mean that cancer has spread to the brain and/or spinal cord.

What is the function of β 2 microglobulin?

Impaired renal function and hyperproduction of beta 2-microglobulin are both associated with increased serum levels. A function for beta 2-microglobulin as a modulator of lymphocyte surface and as a potential regulator of the immune system is proposed.

What causes high beta 2 microglobulin?

Conditions associated with an increased rate of cell production or destruction, severe infections, viral infections such as CMV (cytomegalovirus), and some conditions that activate the immune system, such as inflammatory conditions and autoimmune disorders, can cause increases in beta-2 microglobulin levels, but the …

What is a normal beta-2 microglobulin?

Urine beta2 microglobulin values indicate renal filtration disorders. Measurement of values in both serum and urine can help distinguish a problem of cellular activation from a renal disorder. Normal findings : Blood: 0.70-1.80 mcg/mL.

What is a normal beta 2 microglobulin?

Is Beta 2 microglobulin the same as beta globulin?

Beta globulins are a group of globular proteins in plasma that are more mobile in alkaline or electrically charged solutions than gamma globulins, but less mobile than alpha globulins. Examples of beta globulins include: beta-2 microglobulin.

What is AA amyloidosis?

Overview. AA Amyloidosis is caused by the accumulation of Serum Amyloid A protein into amyloid fibrils causing organ dysfunction. It is usually a complication of patients who have states of chronic inflammation as the inflammation causes a heightened production of this particular protein.

Is Beta-2 microglobulin the same as beta globulin?

What does elevated beta 2 mean?

Beta 2 micro globulin is a component molecule of the cells in the human body. Its levels tend to be elevated when a person is suffering from a particular type of cancer. This feature of the Beta 2 micro globulin makes it useful in the diagnosis of various types of diseases.

What is B2 microglobulin test?

The beta-2 microglobulin ( B2M ) blood test is used to help detect kidney damage and follow kidney disorders, to help evaluate the severity and prognosis of certain cancers such as multiple myeloma and some lymphomas, and it is sometimes used to monitor people who are exposed to cadmium.

What is beta 2 micro?

Beta-2 microglobulin ( b2m ) is a naturally occurring protein in the human body. It is one of two polypeptide chains that make up the structure of a major histocompatibility complex (MHC) Class I molecule. Certain characteristics of b2m make it suitable for detecting tumor cells, especially in blood and kidney cells.

What does a high beta 2 globulin mean? People with cancers of the bone marrow and blood often have high levels of B2M in their blood or urine. These cancers include multiple myeloma, lymphoma, and leukemia. High levels of B2M in cerebrospinal fluid can mean that cancer has spread to the brain and/or spinal cord.…