What is a TSH antagonist?

What is a TSH antagonist?

A selective TSH receptor antagonist inhibits stimulation of thyroid function in female mice. Endocrinology.

What do TSH receptors do?

The thyrotropin (TSH) receptor plays a preeminent role in thyroid physiology and disease. TSH, acting through the TSH receptor, is the major stimulator of thyroid cell growth, differentiation and function. In Graves’ disease, the TSH receptor is the target of stimulating antibodies that cause hyperthyroidism.

Where is T3 and T4 produced?

The thyroid gland is essential to the endocrine system. It is located in front of the neck and is responsible for the production of thyroid hormones. The thyroid gland releases triiodothyronine (T3) and thyroxine (T4).

What happens when TSH binds to its receptors?

Upon binding circulating TSH, a G-protein signal cascade activates adenylyl cyclase and intracellular levels of cAMP rise.

How do I activate my TSH?

Exercise will force the body to burn more calories and use more energy. Iodine is needed for the body to be able to produce the thyroid-stimulating hormone (TSH) that activates the thyroid.

Is TSI and TRAb the same?

TSI assays have a theoretical advantage over TRAb assays in the case of ATD monitoring since they provide an exact measurement of the circulating TSAb activating the thyroid. Conversely, TRAb assay titers will be affected by the various concentrations of TSI, and/or TBAb since these assays detect both antibody types.

Can a TSHR antagonist be used as an inverse agonist?

Therefore, TSHR antagonists/inverse agonists could be used as probes of extrathyroidal TSHR function.

Are there antibodies that bind to the TSH receptor?

Autoantibodies in autoimmune thyroid disease (AITD) bind to the TSH receptor (TSHR) and can act as either agonists, mimicking the biological activity of TSH, or as antagonists inhibiting the action of TSH. Furthermore, some antibodies with antagonist activity can also inhibit the constitutive activity of the TSHR, that is, act as inverse agonists.

How are inverse agonists used to treat thyroid cancer?

Finally, TSHR inverse agonists, which are a subclass of antagonists that inhibit agonist-independent (or basal or constitutive) TSHR signaling, could be used to inhibit TSH-independent signaling in patients with recurrent or metastatic thyroid cancer who are receiving thyroid hormone to suppress TSH.

Who are the antagonists of the thyroid stimulating hormone receptor?

This bioassay record (AID 504821) belongs to the assay project ” Antagonists of the Thyroid Stimulating Hormone Receptor: Summary “, which is associated with the summary AID 504813 and a total of 8 additional BioAssay records in PubChem.

What is a TSH antagonist? A selective TSH receptor antagonist inhibits stimulation of thyroid function in female mice. Endocrinology. What do TSH receptors do? The thyrotropin (TSH) receptor plays a preeminent role in thyroid physiology and disease. TSH, acting through the TSH receptor, is the major stimulator of thyroid cell growth, differentiation and function. In…