What is the difference between TTP and HUS?

HUS is characterized by thrombocytopenia, anaemia and renal insufficiency, whereas the pentad of signs and symptoms including thrombocytopenia, anaemia, neurologic deficit, renal dysfunction and fever is observed in TTP.

Is ITP and TTP the same?

Are ITP and TTP the same thing? No, ITP and TTP are not the same thing. Both ITP and TTP are bleeding disorders, but they occur for different reasons and may require different treatments.

What is the cause of TTP?

This form or TTP is considered to be an autoimmune disease and is caused when patients develop an antibody against the ADAMTS13 protease leading to low levels of the protease. If the disorder is present at birth (familial form), signs and symptoms may typically appear earlier, in infancy or early childhood.

What is the treatment for HUS?

HUS is generally treated with medical care in the hospital. Close attention to fluid volume is very important. This potentially includes intravenous (IV) fluids and nutritional supplementation by IV or tube feeding. A transfusion of blood may also be needed.

Is D-dimer elevated in TTP?

D-dimer and fibrinogen assay findings are as follows: D-dimers are indicative of fibrinolysis and thus, thrombin activation, which usually is normal or mildly elevated in patients with TTP.

Can you recover from TTP?

Most patients (over 90 percent) with acquired autoimmune thrombotic thrombocytopenic purpura due to an autoantibody against ADAMTS13 (referred to as immune TTP) ultimately recover following treatment. However, relapse remains an important concern.

How do you manage TTP?

Corticosteroids are commonly given to patients with TTP. Responses to corticosteroid therapy alone have been documented. Increasing evidence supports the use of the anti-CD20 monoclonal antibody rituximab in cases of TTP refractory to plasma exchange, with resolution of acute disease and prolonged remission.

What’s the difference between HUS and TTP Hus?

Although TTP is classically described by a pentad of signs, the more likely clinical scenario involves a patient with unexplained thrombocytopenia and hemo lytic anemia. TTP is often fatal without therapeutic plasma exchange (TPE). Regarding HUS, the tendency is to use the term TTP – HUS and treat with TPE.

Is there a difference between TTP and aHUS?

Significant advances in the treatment of atypical hemolytic uremic syndrome (aHUS) have placed an increased emphasis on the rapid and accurate differentiation of aHUS from acquired thrombotic thrombocytopenic purpura (TTP). (Blood, June 2014)

When does a child have a HUS or TTP?

For unknown reasons aHUS usually occurs in children rather than adults. Unfortunately, there are many less typical patterns of TTP (secondary TTP) and HUS (aHUS) that occur in patients with another chronic medical condition, which may have acted as a trigger.

What is the difference between TTP and HUS? HUS is characterized by thrombocytopenia, anaemia and renal insufficiency, whereas the pentad of signs and symptoms including thrombocytopenia, anaemia, neurologic deficit, renal dysfunction and fever is observed in TTP. Is ITP and TTP the same? Are ITP and TTP the same thing? No, ITP and TTP are…