What is the main reaction in the synthesis of aspirin?
What is the main reaction in the synthesis of aspirin?
Organic Synthesis Experiments The preparation consists of an esterification reaction catalyzed by acid (H2SO4 or H3PO4), where salicylic acid treated with acetic anhydride gives acetylsalicylic acid (aspirin). In this reaction, a hydroxyl group is converted to an ester, with acetic acid as a byproduct.
Why aspirin is called prodrug?
Aspirin was originally considered a prodrug to salicylic acid since it was at that time thought to have the same pharmacodynamic effects as salicylic acid and is rapidly transformed to it in vivo.
Who invented aspirin?
Felix Hoffmann
Aspirin/Inventors
In 1897, Felix Hoffman, a German chemist working for the Bayer company, was able to modify salicylic acid to create acetylsalicylic acid, which was named aspirin (Fig. 1).
Why is aspirin used?
Aspirin is used to reduce fever and relieve mild to moderate pain from conditions such as muscle aches, toothaches, common cold, and headaches. It may also be used to reduce pain and swelling in conditions such as arthritis. Aspirin is known as a salicylate and a nonsteroidal anti-inflammatory drug (NSAID).
What is mechanism of action of aspirin?
The acetyl group of acetylsalicylic acid binds with a serine residue of the cyclooxygenase-1 (COX-1) enzyme, leading to irreversible inhibition. This prevents the production of pain-causing prostaglandins.
What is the chemical formula of aspirin?
C₉H₈O₄
Aspirin/Formula
Is ibuprofen a prodrug?
Prodrug approach is a promising way of overcoming gastrotoxicity associated with long term oral use of NSAIDs like ibuprofen. The candidature of benzyl ester prodrug of ibuprofen was examined to assess its ability to reduce gastrotoxicity without affecting pharmacological response.
What is prodrug give example?
Prodrug: A precursor (forerunner) of a drug. For example, sulfasalazine is a prodrug. It is not active in its ingested form. It has to be broken down by bacteria in the colon into two products — 5-aminosalicylic acid (5ASA) and sulfapyridine — before becoming active as a drug.
When was the first aspirin?
The aspirin we know came into being in the late 1890s in the form of acetylsalicylic acid when chemist Felix Hoffmann at Bayer in Germany used it to alleviate his father’s rheumatism, a timeline from Bayer says. Beginning in 1899, Bayer distributed a powder with this ingredient to physicians to give to patients.
What is the main reaction in the synthesis of aspirin? Organic Synthesis Experiments The preparation consists of an esterification reaction catalyzed by acid (H2SO4 or H3PO4), where salicylic acid treated with acetic anhydride gives acetylsalicylic acid (aspirin). In this reaction, a hydroxyl group is converted to an ester, with acetic acid as a byproduct. Why…