What is tirofiban used for?

TIROFIBAN blocks platelets from forming blood clots. It is used to prevent complications during episodes of chest pain or a heart attack, or during a procedure to treat a blocked artery of the heart.

Is tirofiban reversible?

Tirofiban is a reversible, competitive inhibitor of GP IIb/IIIa receptors, exerting its effects via the prevention of the binding of fibrinogen and other ligands, resulting in the inhibition of the last common step of thrombi formation.

What type of drug is tirofiban?

Aggrastat belongs to a class of drugs called Antiplatelet Agents, Cardiovascular; Glycoprotein IIb/IIIa Inhibitors.

How does tirofiban work?

Tirofiban works by preventing platelets in the blood from sticking to each other. When platelets stick to each other, they may form blood clots that may cause a heart attack or cause the opened blood vessel in the heart to close back up.

How do you reverse tirofiban?

Tirofiban can be stopped before the procedure, but currently there is no available reversible agent. As a result, platelet transfusion may be needed for reversing the effect.

What drug class is cangrelor?

Cangrelor is used is used during percutaneous coronary intervention (PCI) for reducing the risk of heart attacks, repeat coronary revascularization, and stent thrombosis (ST) in patients who have not been treated with another P2Y12 platelet inhibitor and are not receiving a glycoprotein IIb/IIIa inhibitor, another …

What is the half-life of tirofiban?

Adenosine diphosphate (ADP)-induced platelet aggregation returns to near-baseline levels within 4 to 8 hours after cessation of a tirofiban infusion, a finding consistent with the drug’s elimination half-life of approximately 2 hours.

How long does Aggrastat last?

Infusion of Aggrastat and unfractionated heparin may be continued during coronary angiography and should be maintained for at least 12 hours and not more than 24 hours after angioplasty/atherectomy.

How do I reverse eptifibatide?

There is no available reversible agent for eptifibatide. Therefore, platelet transfusion is the option to reverse the effect of the drug. Tirofiban (Aggrastat) is a low-molecular-weight nonpeptide (molecular weight, 495 Da) that competitively inhibits glycoprotein IIb/IIIa receptor.

How long does cangrelor last?

Cangrelor has a 3-6-minute plasma half-life with rapid platelet function recovery within 30-60 minutes after discontinuation of infusion.

Is dipyridamole a blood thinner?

This medication is used in combination with “blood thinners” such as warfarin to keep clots from forming after heart valve replacements. Clots are a serious complication that can cause strokes, heart attacks, or blocked blood vessels in the lungs (pulmonary embolisms). Dipyridamole is an antiplatelet drug.

How big is the molecular weight of tirofiban?

Tirofiban hydrochloride monohydrate is a white to off-white, non-hygroscopic, free-flowing powder, with a molecular weight of 495.08. It is very slightly soluble in water. AGGRASTAT Injection Premixed is supplied as a sterile solution in water for injection, for intravenous use only, in plastic containers.

What is the half life of tirofiban HCl injection?

When given according to the recommended regimen, >90% inhibition is attained by the end of the 30-minute infusion. Platelet aggregation inhibition is reversible following cessation of the infusion of AGGRASTAT. Pharmacokinetics Tirofiban has a half-life of approximately 2 hours.

Are there any side effects to taking tirofiban?

You should not receive tirofiban if you have any active internal bleeding (stomach, intestines, etc), a history of bleeding or blood-clotting disorder, if you have ever had low blood platelets after being treated with tirofiban, or if you have had any type of surgery, injury, or medical emergency within the past 30 days.

How does tirofiban work to prevent blood clots?

Tirofiban helps to prevent platelets in your blood from sticking together and forming a blood clot. An unwanted blood clot can occur with certain heart or blood vessel conditions.

What is tirofiban used for? TIROFIBAN blocks platelets from forming blood clots. It is used to prevent complications during episodes of chest pain or a heart attack, or during a procedure to treat a blocked artery of the heart. Is tirofiban reversible? Tirofiban is a reversible, competitive inhibitor of GP IIb/IIIa receptors, exerting its effects…