Is Neurofibromatosis an autoimmune disease?

Background: Neurofibromatosis type 1 is an autosomal dominant neurocutaneous disorder in which coexistence with autoimmune thyroiditis and thyroid gland tumours has been reported previously.

What is fn1 disease?

Neurofibromatosis type 1 (NF1) is a genetic condition that causes tumours to grow along your nerves. The tumours are usually non-cancerous (benign) but may cause a range of symptoms. Neurofibromatosis type 2 (NF2) is much less common than NF1.

How does Neurofibromatosis type 1 affect the body?

NF1 can cause curvature of the spine (scoliosis) that may need bracing or surgery. NF1 is also associated with decreased bone mineral density, which increases the risk of weak bones (osteoporosis). Vision problems. Sometimes a tumor develops on the optic nerve (optic glioma), which can affect vision.

Is neurofibromatosis considered a disability?

Although neurofibromatosis is a serious condition, the Social Security Administration (SSA) does not specifically list the disorder as a disability. But, the symptoms that accompany the condition can be reviewed for benefits.

What body systems are affected by neurofibromatosis?

Neurofibromatosis is not a single medical disorder but refers to three different conditions involving the development of tumors that may affect the brain, spinal cord, and the nerves that send signals between the brain and spinal cord and all other parts of the body.

How is neurofibromatosis type 1 caused by mutations?

We want to hear from you. Neurofibromatosis type 1 is caused by changes ( mutations) in the NF1 gene. NF1 is a tumor suppressor gene, which means that it encodes a protein that stops cells from growing and dividing too rapidly or in an uncontrolled way. Mutations in NF1 result in an abnormal protein that is unable to carry out its normal role.

What is the prognosis for neurofibromatosis type 1?

The long-term outlook ( prognosis) for people with neurofibromatosis type 1 (NF1) varies based on the severity of the condition and the signs and symptoms present in each person. Although people with NF1 can live relatively long and healthy lives, their life expectancy tends to be lower than in the general population. [7]

How does a neurofibromatosis registry support research?

A registry supports research by collecting of information about patients that share something in common, such as being diagnosed with Neurofibromatosis type 1. The type of data collected can vary from registry to registry and is based on the goals and purpose of that registry.

How is NF1 inherited in the autosomal dominant manner?

NF1 is caused by changes ( mutations) in the NF1 gene and is inherited in an autosomal dominant manner. In about 50% of cases, it is inherited from an affected parent. Other cases result from a new ( de novo) mutation, occurring for the first time in people with no family history of NF1.

Is Neurofibromatosis an autoimmune disease? Background: Neurofibromatosis type 1 is an autosomal dominant neurocutaneous disorder in which coexistence with autoimmune thyroiditis and thyroid gland tumours has been reported previously. What is fn1 disease? Neurofibromatosis type 1 (NF1) is a genetic condition that causes tumours to grow along your nerves. The tumours are usually non-cancerous (benign)…