Is ritodrine a beta agonist?
Is ritodrine a beta agonist?
Ritodrine is beta-2 adrenergic agonist. It stimulates beta-2 adrenergic receptor, increases cAMP level and decreases intracellular calcium concentration. The decrease of calcium concentration leads to a relaxation of uterine smooth muscle and, therefore, a decrease in premature uterine contractions.
What are beta-mimetics?
Abstract. Selective beta-mimetic drugs are the most frequently used agents for arresting preterm labour. For this purpose these drugs have to be given in high doses for several hours and since they act on several organ systems, side-effects, some of which are potentially dangerous, appear.
Which drug can be used as alternative to ritodrine?
A major concern are the marked side effects of beta-mimetics. The calcium channel blocker nifedipine has been used for tocolysis shortly after its introduction in clinical practice and is considered to be a probable good alternative for ritodrine.
Why was ritodrine discontinued?
The production of oral ritodrine was discontinued in 1995 because of issues concerning the dose and efficacy of the drug in women in preterm labor. Oral terbutaline is a more cost-effective alternative.
What class of drug is Atosiban?
G02CX01 – atosiban ; Belongs to the class of other gynecologicals. Used to inhibit uncomplicated premature labour between 24 and 33 weeks of gestation.
Is terbutaline a beta blocker?
Terbutaline is a beta-adrenergic receptor agonist. In vitro and in vivo pharmacologic studies have demonstrated that terbutaline exerts a preferential effect on beta2-adrenergic receptors.
Is oxytocin a tocolytic?
Oxytocin receptor antagonists (OTR-A) have been developed as tocolytics for the management of preterm labour due to the significant role of oxytocin (OT) in the onset of both term and preterm labour. Similar to OT, prostaglandins (PGs) play key roles in myometrial contractility and cervical ripening.
Is ethanol a tocolytic?
Ethanol infused in intoxicating doses was the first clinically useful tocolytic agent, but because of its potential risks to the fetus, its use is now infrequent. We have examined the efficacy of ethanol infused at much lower rates, alone or in combination with ritodrine, to inhibit preterm uterine contractions.
Is ritodrine a tocolytic?
Both ritodrine and terbutaline are used as tocolytic agents, but only ritodrine is approved by the Food and Drug Administration for this use. Ritodrine is administered by continuous intravenous infusion and titrated in response to the uterine contraction pattern.
Is ritodrine as tocolytic?
Is Procardia a tocolytic?
CONCLUSION. Nifedipine appears to be superior to β2-adrenergic-receptor agonists and magnesium sulfate and should be considered as the first-line tocolytic agent for the management of preterm labor.
What kind of drug is ritodrine used for?
Ritodrine is only found in individuals that have used or taken this drug. It is an adrenergic beta-agonist used to control premature labor. [PubChem]Ritodrine is beta-2 adrenergic agonist.
How is ritodrine used to treat premature labor?
Ritodrine is an adrenergic beta-2 agonist used to control PREMATURE LABOR. Ritodrine is a phenethylamine derivative with tocolytic activity. Ritodrine binds to and activates beta-2 adrenergic receptors of myometrial cells in the uterus, which decreases the intensity and frequency of uterine contractions.
Why does ritodrine increase the production of Camp?
Specifically, ritodrine probably activates adenyl cyclase, thereby increasing production of cyclic adenosine monophosphate ( cAMP ), which in turn enhances the efflux of calcium from vascular smooth muscle cells. A lack of intracellular calcium prevents uterine myometrial contractions.
What is the molecular formula for ritodrine Pubchem CID 33572?
Ritodrine PubChem CID 33572 Structure Find Similar Structures Molecular Formula C17H21NO3 Synonyms ritodrine Yutopar Ritodrina [INN-Spanish Molecular Weight 287.35
Is ritodrine a beta agonist? Ritodrine is beta-2 adrenergic agonist. It stimulates beta-2 adrenergic receptor, increases cAMP level and decreases intracellular calcium concentration. The decrease of calcium concentration leads to a relaxation of uterine smooth muscle and, therefore, a decrease in premature uterine contractions. What are beta-mimetics? Abstract. Selective beta-mimetic drugs are the most frequently…