What are Antimonial drugs?

Antimonials, in pre-modern medicine, were remedies principally containing antimony, used chiefly for emetic purposes. They might also have qualified for cathartic, diaphoretic, or simply alternative uses. Such treatments were considered unparalleled in their strength.

What is the mechanism of action of sodium stibogluconate?

Mechanism of action and use Sodium stibogluconate is an organic antimony derivative. Its mechanism is unclear but it may act by binding to thiol groups in the parasite and inhibiting the formation of high-energy phosphates (ATP and guanosine triphosphate [GTP]). It is used to treat visceral leishmaniasis.

When was sodium stibogluconate first used to treat leishmaniasis?

Pentavalent antimonials (Pentostam, Glaxo Smith Kline, United Kingdom) has been used to treat leishmaniasis for more than 50 years….Use of Sodium Stibogluconate as a Treatment for Leishmaniasis.

Actual Study Start Date :	October 2004
Actual Primary Completion Date :	April 2010
Actual Study Completion Date :	April 2015

Is sodium stibogluconate safe in pregnancy?

Background: Kala-azar in pregnant women is difficult to treat because for them the two commonly used drugs, sodium stibogluconate and pentamidine, are not considered safe.

How is sodium stibogluconate given?

Sodium stibogluconate is usually administered by intravenous or intramuscular injection daily at a dose of 20 mg/kg/day (maximum 850 mg) for 21–28 days. Intralesional injections may be used for a single lesion or a few small lesions of cutaneous leishmaniasis.

What is Antimonial compound?

From Wikipedia, the free encyclopedia. Pentavalent antimonials (also abbreviated pentavalent Sb or SbV) are a group of compounds used for the treatment of leishmaniasis. They are also called pentavalent antimony compounds.

What is another name for praziquantel?

BILTRICIDE® (praziquantel) is a trematodicide provided in tablet form for the oral treatment of schistosome infections and infections due to liver fluke.

How do you administer sodium stibogluconate?

What does sodium stibogluconate treat?

Sodium stibogluconate (SSG) is an Investigational New Drug (IND) product that has been in use by the Department of Defense (DoD) for over 20 years for the treatment of cutaneous, mucosal and visceral leishmaniasis….Use of Sodium Stibogluconate as a Treatment for Leishmaniasis.

Last Update Posted:	January 2, 2020
Last Verified:	December 2019

Which of the following drugs is used to treat leishmaniasis?

Sodium stibogluconate (Pentostam) Sodium stibogluconate has been the drug of choice for the treatment of cutaneous and mucocutaneous leishmaniasis in the United States. This agent is also effective against visceral leishmaniasis and is often the first-line treatment outside the United States.

How do you give sodium stibogluconate?

What is amphotericin used for?

Amphotericin B is an antifungal medication that fights infections caused by fungus. Amphotericin B is used to treat serious, life-threatening fungal infections.

What are Antimonial drugs? Antimonials, in pre-modern medicine, were remedies principally containing antimony, used chiefly for emetic purposes. They might also have qualified for cathartic, diaphoretic, or simply alternative uses. Such treatments were considered unparalleled in their strength. What is the mechanism of action of sodium stibogluconate? Mechanism of action and use Sodium stibogluconate is…