What is a high beta-2 microglobulin?

Purpose: Elevated serum beta-2 microglobulin (beta 2M) levels are associated with poor prognosis in several lymphoproliferative disorders including multiple myeloma and lymphoma. Their prognostic relevance in acute lymphocytic leukemia (ALL) is unknown.

What is beta-2 microglobulin amyloidosis?

Beta-2 ̶ microglobulin (beta-2m) amyloidosis is a disabling condition that affects patients undergoing long-term hemodialysis (HD) or continuous ambulatory peritoneal dialysis (CAPD). Case reports involving patients with near ̶ end-stage renal disease also exist.

What is a high level of B2M?

High levels of B2M indicate a problem but cannot diagnose a specific condition. However, they do reflect the activity or significance of a cancer, if present. In an individual with multiple myeloma or lymphoma, high levels of B2M are associated with a less positive prognosis.

What does high beta globulin mean?

Elevated beta-globulin levels may be indicative of chronic liver or kidney disease, or chronic inflammatory diseases such as aspergillosis or avian chlamydiosis. The most common reason for elevated beta globulins in birds, which is attributable to the transferrin component, is egg production.

What is the normal range for Beta 2 microglobulin?

Reference Range Normal findings : Blood: 0.70-1.80 mcg/mL. Urine: ≤300 mcg/L.

What is the effect of β2 microglobulin on MHC I molecules?

Structure and function β2 microglobulin lies beside the α3 chain on the cell surface. In cytomegalovirus infection, a viral protein binds to β2 microglobulin, preventing assembly of MHC class I molecules and their transport to the plasma membrane.

What is a normal beta 2 microglobulin level?

Urine beta2 microglobulin values indicate renal filtration disorders. Measurement of values in both serum and urine can help distinguish a problem of cellular activation from a renal disorder. Normal findings : Blood: 0.70-1.80 mcg/mL.

How does a person get multiple myeloma?

What causes multiple myeloma? The exact cause of multiple myeloma is unknown. However, it starts with one abnormal plasma cell that rapidly multiplies in the bone marrow many more times than it should. The resulting cancerous myeloma cells don’t have a normal life cycle.

What causes high beta globulin levels?

Other common conditions that may lead to high globulin levels being noted in the liver function test include Tuberculosis, kidney disease, autoimmune disease, Carcinoid syndrome, bone marrow disorder and liver disease may cause your globulin levels to be high.

What is the normal range for beta globulin?

Normal range of globulins is 2.3-3.5 gm/dL. Alpha globulin range is 0.2-0.3 g/L and optimal beta globulin range is 0.7-1.0 g/L.

What does elevated beta 2 mean?

Beta 2 micro globulin is a component molecule of the cells in the human body. Its levels tend to be elevated when a person is suffering from a particular type of cancer. This feature of the Beta 2 micro globulin makes it useful in the diagnosis of various types of diseases.

What is beta 2 micro?

Beta-2 microglobulin ( b2m ) is a naturally occurring protein in the human body. It is one of two polypeptide chains that make up the structure of a major histocompatibility complex (MHC) Class I molecule. Certain characteristics of b2m make it suitable for detecting tumor cells, especially in blood and kidney cells.

What is a high beta-2 microglobulin? Purpose: Elevated serum beta-2 microglobulin (beta 2M) levels are associated with poor prognosis in several lymphoproliferative disorders including multiple myeloma and lymphoma. Their prognostic relevance in acute lymphocytic leukemia (ALL) is unknown. What is beta-2 microglobulin amyloidosis? Beta-2 ̶ microglobulin (beta-2m) amyloidosis is a disabling condition that affects patients…