What is CMP sialic acid?

Cytidine 5′-monophosphate (CMP)-sialic acid synthetase (CSS) is an essential enzyme involved in the biosynthesis of carbohydrates and glycoconjugates containing sialic acids, a class of α-keto acids that are generally terminal key recognition residues by many proteins that play important biological and pathological …

What is the role of sialic acid in relation to glycoproteins?

Function. Sialic acid containing glycoproteins (sialoglycoproteins) bind selectin in humans and other organisms. Sialic acid can “hide” mannose antigens on the surface of host cells or bacteria from mannose-binding lectin. This prevents activation of complement.

What is Nana biochemistry?

N-Acetylneuraminic acid (Neu5Ac or NANA) is the predominant sialic acid found in human cells, and many mammalian cells. Other forms, such as N-Glycolylneuraminic acid, may also occur in cells.

What does Sialylation mean?

Sialylation, or the covalent addition of sialic acid to the terminal end of glycoproteins, is a biologically important modification that is involved in embryonic development, neurodevelopment, reprogramming, oncogenesis and immune responses.

Where is sialic acid found?

Sialic acids also exist in many human body fluids including saliva, gastric juice, serum, urine, tears, and human milk (Table 2). Free sialic acid is found in urine, particularly in patients with the disease sialuria, where up to 7 g of sialic acid can be eliminated in 1 day (Montreuil et al, 1968).

What is CMP Nana?

CMP-N-Acetylneuraminic Acid is an activated sugar, and can be used for in vitro glycoengineering of glycoproteins, e.g. therapeutic proteins. CMP-NANA is a sodium salt, provided as a white, lyophilized substance.

Is sialic acid a glycan?

Being particularly prominent on cell surface and secreted molecules, they are also important contributors to many physiological and pathological interactions. This review focuses on one class of sugars called the sialic acids, which are typically found at the outermost end of glycan chains of all cell types [6–8].

What is the role of sialic acid?

Sialic acids (Sias) are nine-carbon atoms sugars usually present as terminal residues of glycoproteins and glycolipids on the cell surface or secreted. They have important roles in cellular communication and also in infection and survival of pathogens.

What is the formula of sialic acid?

C11H19NO9
Sialic acid/Formula

Where is sialic acid found in the human body?

brain
In the human body, the highest concentration of sialic acid (as N-acetylneuraminic acid) occurs in the brain where it participates as an integral part of ganglioside structure in synaptogenesis and neural transmission.

What is CMP sialic acid? Cytidine 5′-monophosphate (CMP)-sialic acid synthetase (CSS) is an essential enzyme involved in the biosynthesis of carbohydrates and glycoconjugates containing sialic acids, a class of α-keto acids that are generally terminal key recognition residues by many proteins that play important biological and pathological … What is the role of sialic acid…