Is Goodpasture syndrome type II hypersensitivity?

Another example of a type II hypersensitivity reaction is Goodpasture’s disease (Chapter 123), in which antibodies against the α3-chain of type IV collagen (the collagen in basement membranes) are deposited in glomerular and lung basement membrane.

What happens in type II hypersensitivity?

Type II hypersensitivity reaction refers to an antibody-mediated immune reaction in which antibodies (IgG or IgM) are directed against cellular or extracellular matrix antigens with the resultant cellular destruction, functional loss, or damage to tissues.

What type of hypersensitivity reaction is Goodpasture syndrome?

[GOODPASTURE’S SYNDROME–CASE REPORTS] Autoantibodies activate the complement cascade resulting in tissue injury by the type II hypersensitivity reaction according to the Coombs and Gell classification of antigen-antibody reactions.

What is an example of type 2 hypersensitivity?

One of the most common examples of type II hypersensitivity is the one following drug intake in patients with drug-induced lupus. In this type, anti-red blood cell or anti-dsDNA antibodies are produced as a result of a drug attaching to red blood cells resulting in drug-induced systemic lupus erythematosus (SLE).

How do you test for type 2 hypersensitivity?

These reactions can only be diagnosed accurately using the drug provocation test (DPT), since skin tests are not reliable and no biological tests are currently available. However, DPT represents a high-risk method of diagnosis testing, as it can reproduce the type 2 hypersensitivity reaction.

What are the 4 types of hypersensitivity reactions?

In 1963, two British immunologists, Robert Coombs and Philip Gell, classified four different types of hypersensitivity reactions:

Immediate (type I) Symptoms appear after a few seconds to minutes.
Cytotoxic (type II)
Immune complex-mediated (type III)
Delayed hypersensitivity (type IV)

What kind of disease does Goodpasture syndrome cause?

Summary Summary. Goodpasture syndrome is an autoimmune disease that affects the lungs and kidneys and is characterized by pulmonary alveolar hemorrhage (bleeding in the lungs) and a kidney disease known as glomerulonephritis.

Are there any HLA antigens in Goodpasture syndrome?

Below we have provided some facts regarding HLA antigens and Goodpasture syndrome: A certain HLA antigen, HLA-DR15 (previously known as HLA-DR2), is found in 88% of patients with Goodpasture syndrome, as compared to 25-32% of those without it.

What is the name of the type II hypersensitivity reaction?

Goodpasture syndrome is a type II hypersensitivity reaction characterized by the presence of nephritis in association with lung hemorrhage. In most patients, it is caused by cross-reactive autoantigens that are present in the basement membranes of the lung and kidney.

How long is the treatment for Goodpasture syndrome?

The duration of the immunosuppressive treatment varies but is typically 6 months for corticosteroids and 3 months for cyclophosphamide. Remove offending agents that may have initiated the antibody production. After hospital discharge, patients require long-term regular visits for monitoring kidney function and for immunosuppressive therapy.

Is Goodpasture syndrome type II hypersensitivity? Another example of a type II hypersensitivity reaction is Goodpasture’s disease (Chapter 123), in which antibodies against the α3-chain of type IV collagen (the collagen in basement membranes) are deposited in glomerular and lung basement membrane. What happens in type II hypersensitivity? Type II hypersensitivity reaction refers to an…